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Cagrisema produced significantly greater percentage weight loss than semaglutide with a mean difference of -7.47% (95% CI: -10.58, -4.36; p < 0.001).
Cagrisema may be a more effective option for weight loss in obese patients compared to semaglutide.
StrongSupportsmedium confidence
Cagrisema produced significantly greater percentage [MD -7.47% (95% CI: -10.58, -4.36); p < 0.001] weight loss than semaglutide.
Why this rating
Based on a systematic review and meta-analysis of randomized controlled trials.
Source
Efficacy and Safety of Cagrilintide and Cagrisema Versus Semaglutide as Anti‐Obesity Medications: A Systematic Review, Meta‐Analysis and Meta‐Regression
Muhammad Ahmed et al. · Diabetes Obesity and Metabolism · 2026
DOI 10.1111/dom.70667
Meta-analysis
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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