Research
Mixed
High body mass index (BMI) is a significant contributor to premature cardiometabolic mortality, particularly in adults aged 45-69, largely mediated through its effects on blood pressure and glucose.
Maintaining a healthy weight is crucial for preventing early death from heart disease or diabetes, especially if you are middle-aged. This risk is often linked to blood pressure and blood sugar levels, so managing weight helps manage those metrics.
GoodSupportsHIGH confidence
High body-mass index (BMI) (42,643 deaths; 95%UI: 40,161 to 45,111)... The relative greater impact of high BMI on premature mortality was mostly due to suboptimal BMI among adults between 45 and 69 years of age.
Why this rating
Based on GBD data and meta-analyses.
Source
The Impact of Dietary and Metabolic Risk Factors on Cardiovascular Diseases and Type 2 Diabetes Mortality in Brazil
Marcia C. de Oliveira Otto et al. · PLoS ONE · 2016
DOI 10.1371/journal.pone.0151503
cohort · n=34003Cited 73×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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