Research
Hormonal
A weight reduction of 5% or more occurred in 100% of participants who received 8 mg of retatrutide.
The 8 mg dose of retatrutide is highly effective for achieving at least a 5% weight loss in this population.
StrongSupportsmedium confidence
100% of those who received 8 mg... had occurred in 100%, 91%, and 75% of those who received 8 mg.
Why this rating
Based on a phase 2, double-blind, randomized, placebo-controlled trial design.
Source
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Ania M. Jastreboff et al. · New England Journal of Medicine · 2023
rct · n=338Cited 940×
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