Research
Cellular
The most common adverse events in the retatrutide groups were gastrointestinal and were mostly mild to moderate in severity.
Practitioners should monitor for gastrointestinal side effects in patients treated with retatrutide.
StrongQualifiesmedium confidence
The most common adverse events in the retatrutide groups were gastrointestinal; these events were dose-related, were mostly mild to moderate in severity.
Why this rating
Based on a phase 2, double-blind, randomized, placebo-controlled trial design.
Source
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Ania M. Jastreboff et al. · New England Journal of Medicine · 2023
DOI 10.1056/nejmoa2301972
rct · n=338Cited 940×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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