Research
Energy balance
Treatment with once-weekly injectable semaglutide resulted in a mean change in body weight of -13.7% compared to -3.2% with placebo (P<0.001).
Semaglutide may be an effective treatment for weight loss in obese individuals with knee osteoarthritis.
StrongSupportsmedium confidence
The mean change in body weight from baseline to week 68 was -13.7% with semaglutide and -3.2% with placebo (P<0.001).
Why this rating
Based on a large randomized controlled trial design.
Source
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
Henning Bliddal et al. · New England Journal of Medicine · 2024
rct · n=407Cited 306×
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