Research
Hormonal
Hypoaminoacidemia associated with insulin treatment blunts the responsiveness of insulin's suppression of protein breakdown.
Maintaining amino acid levels is crucial for maximizing insulin's effects on protein metabolism.
StrongSupportsmedium confidence
Observed differences in INS's suppression of LEU Ra between the two protocols suggests the existence of a component of whole body proteolysis that is highly dependent on circulating plasma AA.
Why this rating
Based on study design from abstract.
Source
Amino acids augment insulin's suppression of whole body proteolysis
Paul J. Flakoll et al. · American Journal of Physiology-Endocrinology and Metabolism · 1989
DOI 10.1152/ajpendo.1989.257.6.e839
otherCited 148×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Insulin infusions without amino acids resulted in a progressive decrement in leucine Ra (14 to 45%), NORd (16-41%), and OXRd (3-56%) compared with basal values.Strong
- The infusion of amino acids resulted in an additional reduction in endogenous Ra and a blunting of NORd reduction at each dose of insulin.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →