Research
Hormonal
Tirzepatide (15 mg once weekly) resulted in weight loss of up to 17.8% after 72 weeks of therapy.
Tirzepatide is an effective option for weight loss in adults without diabetes.
StrongSupportsmedium confidence
Compared with placebo, tirzepatide (15 mg once weekly) resulted in weight loss of up to 17.8% (95% CI, 16.3% to 19.3%) after 72 weeks of therapy.
Why this rating
Based on the inclusion of randomized controlled trials.
Source
Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes
Areesha Moiz et al. · Annals of Internal Medicine · 2025
DOI 10.7326/annals-24-01590
rctCited 108×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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