Research
Hormonal
GLP-1 receptor agonists and co-agonists are efficacious for weight loss with safety concerns predominantly gastrointestinal.
Practitioners should consider GLP-1 RAs for weight management, noting gastrointestinal side effects.
StrongSupportsmedium confidence
GLP-1 RAs and co-agonists are efficacious for weight loss, with reported safety concerns predominantly gastrointestinal in nature.
Why this rating
The findings are based on randomized controlled trials.
Source
Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes
Areesha Moiz et al. · Annals of Internal Medicine · 2025
DOI 10.7326/annals-24-01590
rctCited 108×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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