Research
Hormonal
There is a causal relationship between glucose-stimulated insulin secretion and body weight.
Practitioners should consider the role of insulin secretion in weight management strategies.
StrongSupportsmedium confidence
Mendelian randomization analyses provide evidence for a causal relationship of glucose-stimulated insulin secretion on body weight.
Why this rating
Based on the use of Mendelian randomization and large sample sizes.
Source
Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity
Christina M. Astley et al. · Clinical Chemistry · 2018
DOI 10.1373/clinchem.2017.280727
Meta-analysisCited 84×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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