Research
Energy balance
Higher genetically determined BMI is not associated with insulin secretion.
This suggests that BMI may not directly influence insulin secretion, which could inform treatment approaches.
StrongRefutesmedium confidence
By contrast, higher genetically determined BMI was not associated with insulin-30.
Why this rating
Based on the analysis of genetic data.
Source
Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity
Christina M. Astley et al. · Clinical Chemistry · 2018
DOI 10.1373/clinchem.2017.280727
Meta-analysisCited 84×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →