Research
Metabolic adaptation
Glycogen-depleting exercise and a high-carbohydrate diet resulted in a 300% increase in muscle glycogen content compared to a low-carbohydrate condition.
Practitioners should consider the significant impact of carbohydrate intake on muscle glycogen replenishment post-exercise.
StrongSupportsmedium confidence
Glycogen-depleting exercise and HIGH-CHO resulted in a 300% increase in muscle glycogen content (P < 0.001) relative to the LOW-CHO condition.
Why this rating
The study design involves controlled dietary manipulation and exercise intervention.
Source
Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation
Melissa J. Arkinstall et al. · American Journal of Physiology-Endocrinology and Metabolism · 2004
DOI 10.1152/ajpendo.00557.2003
other · n=7Cited 83×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The exercise-diet manipulation significantly affected the transcription of all carbohydrate-related genes, increasing GLUT4 and glycogenin mRNA abundance after a high-carbohydrate diet.Strong
- Low-carbohydrate conditions resulted in twofold higher free fatty acid concentrations compared to high-carbohydrate conditions.Strong
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