Research
Hormonal
Mean 24-h circulating leptin concentration decreased by -44 ± 3% (P < 0.001) after CR.
Caloric restriction significantly reduces leptin levels, which may affect energy expenditure.
StrongSupportsmedium confidence
Mean 24-h circulating leptin concentration decreased by -44 ± 3% (P < 0.001).
Why this rating
Based on a randomized controlled trial design.
Source
The Fall in Leptin Concentration Is a Major Determinant of the Metabolic Adaptation Induced by Caloric Restriction Independently of the Changes in Leptin Circadian Rhythms
Virgile Lecoultre et al. · The Journal of Clinical Endocrinology & Metabolism · 2011
DOI 10.1210/jc.2011-1286
rct · n=48Cited 80×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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