Research
Metabolic adaptation
Six months of caloric restriction (CR) decreased body weight by -11.4 ± 0.6% (P < 0.001).
Caloric restriction can lead to significant weight loss over six months.
StrongSupportsmedium confidence
Six months of CR decreased body weight by -11.4 ± 0.6% (mean ± sem; P < 0.001).
Why this rating
Based on a randomized controlled trial design.
Source
The Fall in Leptin Concentration Is a Major Determinant of the Metabolic Adaptation Induced by Caloric Restriction Independently of the Changes in Leptin Circadian Rhythms
Virgile Lecoultre et al. · The Journal of Clinical Endocrinology & Metabolism · 2011
DOI 10.1210/jc.2011-1286
rct · n=48Cited 80×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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