Research
Metabolic adaptation
A minimum study duration and a minimum gain in HbA1c reduction are necessary to drive a relevant risk reduction in CVD risk.
Clinical interventions should focus on achieving significant HbA1c reductions over adequate durations to effectively reduce cardiovascular risk.
StrongSupportsmedium confidence
The results suggest that a minimum study duration and a minimum gain in glycated haemoglobin (HbA1c) reduction are necessary to drive a relevant risk reduction in CVD risk.
Why this rating
The claim is based on analysis of randomized controlled trials.
Source
Prevention of cardiovascular disease through reduction of glycaemic exposure in type 2 diabetes: <scp>A</scp> perspective on glucose‐lowering interventions
Ronan Roussel et al. · Diabetes Obesity and Metabolism · 2017
DOI 10.1111/dom.13033
reviewCited 64×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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