Mixed
In Thai adults with obesity and metabolic syndrome, a 12-week lifestyle education intervention combined with partial meal replacement (two meals daily) produces significantly greater weight loss and glycemic improvement than lifestyle education alone.
If you have obesity and metabolic syndrome, replacing two of your daily meals with a high-protein meal replacement shake, while also receiving basic lifestyle education on diet and exercise, will help you lose more weight and improve your blood sugar levels compared to just receiving lifestyle education alone. However, be aware that this benefit is most pronounced during the 12-week intervention period, and long-term maintenance requires ongoing support or continued use of the strategy.
At 12 weeks, LEI + MR achieved greater %WL than LEI (p < 0.05, Table 2)... FPG was significantly reduced in LEI + MR at 12 weeks compared to baseline but not in LEI group, consequently LEI + MR group experienced a significantly lower level of FPG than LEI, p < 0.05
Why this rating
Randomized controlled trial with adequate allocation concealment, though sample size was smaller than planned and follow-up was limited to 64 weeks.
Source
Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial
Kusuma Chaiyasoot et al. · Nutrition and Diabetes · 2018
DOI 10.1038/s41387-018-0034-0
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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