Research
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Mean percentage weight change at 1 year was -5.1% with semaglutide compared to -2.2% with liraglutide (P < .001).
Semaglutide may be more effective than liraglutide for weight loss in clinical practice.
StrongSupportsmedium confidence
Mean (SD) percentage weight change at 1 year was -5.1% (7.8%) with semaglutide vs -2.2% (6.4%) with liraglutide (P < .001).
Why this rating
Based on a large retrospective cohort study.
Source
One-Year Weight Reduction With Semaglutide or Liraglutide in Clinical Practice
Hamlet Gasoyan et al. · JAMA Network Open · 2024
DOI 10.1001/jamanetworkopen.2024.33326
cohort · n=3389Cited 58×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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