Research
Energy balance
Treatment with liraglutide 3.0 mg provides a statistically significant and clinically meaningful weight loss of 5.7%-8.0% compared to 1.6%-2.6% with placebo.
Liraglutide 3.0 mg can be an effective treatment for weight management in individuals without T2DM.
StrongSupportsmedium confidence
treatment with liraglutide 3.0 mg for weight management provides a statistically significant and clinically meaningful weight loss of 5.7%-8.0% compared to 1.6%-2.6% with placebo.
Why this rating
Based on data from three randomized, placebo-controlled trials.
Source
Liraglutide 3.0 mg for weight management: weight-loss dependent and independent effects
Harold Bays et al. · Current Medical Research and Opinion · 2016
DOI 10.1080/03007995.2016.1251892
rct · n=4725Cited 48×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Endpoints predominantly driven by liraglutide-induced weight loss include waist circumference, diastolic blood pressure, triglycerides, high density lipoprotein cholesterol, AHI, and health-related quality of life scores.Strong
- Endpoints predominantly independent of weight loss include hemoglobin A1c and fasting plasma glucose in individuals with and without T2DM.Strong
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →