Research
Metabolic adaptation
Prolonged calorie restriction has been shown to extend both the median and maximal lifespan in a variety of lower species.
Calorie restriction may be a viable strategy for extending lifespan, though this is primarily observed in non-human species.
StrongSupportsmedium confidence
Prolonged calorie restriction has been shown to extend both the median and maximal lifespan in a variety of lower species such as yeast, worms, fish, rats, and mice.
Why this rating
The claim is supported by findings from multiple studies across different species.
Source
Energy restriction and aging
Julie V Smith et al. · Current Opinion in Clinical Nutrition & Metabolic Care · 2004
DOI 10.1097/00075197-200411000-00005
reviewCited 47×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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