Research
Hormonal
Among U.S. Pima Indians, subjects with type 2 diabetes had lower leptin than nondiabetic subjects (difference = 6.9 +/- 1.0 ng/ml, P < 0.002).
Diabetes management may involve monitoring leptin levels as part of metabolic health assessments.
StrongSupportsmedium confidence
Among U.S. Pima Indians, independent of percent fat, subjects with type 2 diabetes had lower leptin than nondiabetic subjects (difference = 6.9 +/- 1.0 ng/ml, P < 0.002).
Why this rating
The claim is supported by a statistically significant difference.
Source
Plasma leptin concentrations in Pima Indians living in drastically different environments.
Caroline S. Fox et al. · Diabetes Care · 1999
DOI 10.2337/diacare.22.3.413
cross-sectional · n=642Cited 47×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Leptin concentration is strongly correlated with percent fat in both Mexican and U.S. Pima Indians (r = 0.83 and r = 0.86, respectively, P < 0.0001).Strong
- Mexican Pima Indians had lower absolute leptin concentrations than U.S. Pima Indians, but higher after adjustment for percent body fat, waist circumference, age, and sex.Strong
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