Research
Energy balance
Semaglutide reduced body weight more in women than in men, with a mean difference of -9.6% in women and -7.2% in men.
Practitioners should note that women may experience greater weight loss with semaglutide treatment.
StrongSupportsmedium confidence
Semaglutide improved body weight more in women (mean difference in women -9.6% [95% CI: -10.9% to -8.4%]; men -7.2% [95% CI: -8.4% to -6.0%]; P interaction = 0.006)
Why this rating
Based on the large randomized controlled trial design.
Source
Efficacy of Semaglutide by Sex in Obesity-Related Heart Failure With Preserved Ejection Fraction
Subodh Verma et al. · Journal of the American College of Cardiology · 2024
DOI 10.1016/j.jacc.2024.06.001
rct · n=1145Cited 47×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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