Research
Energy balance
Baseline metabolite levels (BCAA, tyrosine, betaine, choline) do not predict the magnitude of weight loss achieved after bariatric surgery or lifestyle interventions.
Your baseline blood levels of BCAA, tyrosine, betaine, or choline will not tell you how much weight you will lose after surgery or a diet program. While these markers might predict whether your diabetes remits, they do not predict the magnitude of weight loss.
ModerateRefutesHIGH confidence
No metabolite factors associated with weight loss at five years.
Why this rating
Large sample size for weight loss analysis (n=151 LABS), but no significant associations were found.
Source
Metabolites and diabetes remission after weight loss
Lydia Coulter Kwee et al. · Nutrition and Diabetes · 2021
DOI 10.1038/s41387-021-00151-6
cohort · n=173Cited 50×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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