Hormonal
Higher-quality protein sources (e.g., whey, milk) produce a significantly greater acute muscle protein synthesis (MPS) response than lower-quality sources (e.g., soy, wheat, casein) when matched for dose, both at rest and following resistance exercise.
If you are trying to maximize muscle growth, prioritize high-quality protein sources like whey, milk, eggs, or meat over lower-quality plant proteins (like wheat or soy) when possible. This is especially relevant for older adults who may experience 'anabolic resistance.' However, this is a small effect; hitting your total daily protein target is still the most important factor.
Analysis revealed an effect favoring higher-quality protein for postprandial MPS at rest [mean difference (MD): 0.014%/h; 95% CI: 0.006, 0.021; P < 0.001] and following RE (MD: 0.022%/h; 95% CI: 0.014, 0.030; P < 0.00001) in young... and older... adults.
Why this rating
Systematic review and meta-analysis of 27 studies with dose-matched comparisons.
Source
Protein Source and Quality for Skeletal Muscle Anabolism in Young and Older Adults: A Systematic Review and Meta-Analysis
Paul T. Morgan et al. · Journal of Nutrition · 2021
DOI 10.1093/jn/nxab055
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →