Mixed
South Asian ethnicity is associated with a significantly higher risk of developing Type 2 Diabetes (T2D) and insulin resistance compared to White populations, driven by distinct metabolic signatures including elevated branched-chain amino acids (BCAAs) and altered lipid metabolism.
If you are of South Asian descent, your risk for Type 2 Diabetes is statistically higher than that of White populations, often manifesting at lower BMIs. This is linked to how your body metabolizes amino acids and fats. Focus on monitoring metabolic markers like fasting glucose and insulin sensitivity, and consider dietary patterns that manage carbohydrate intake and support healthy lipid metabolism, as personalized strategies based on these metabolic insights are more effective than generic advice.
Across the world, South Asians display an increased burden of T2D in comparison with population from non-White and White ethnic backgrounds... South Asian ethnicities displayed higher hazard ratios (3.0) than white ethnicities to develop T2D (< 2.0)... South Asians showed four times greater risk of T2D... than White Europeans.
Why this rating
Based on multiple large cohort studies (NHS, THIN, DPoRT, SABRE) cited in the review.
Source
Ethnic disparities attributed to the manifestation in and response to type 2 diabetes: insights from metabolomics
Sampara Vasishta et al. · Metabolomics · 2022
DOI 10.1007/s11306-022-01905-8
More from this paper
- Elevated levels of Branched-Chain Amino Acids (BCAAs) such as leucine, isoleucine, and valine are predictive markers for Type 2 Diabetes risk across multiple ethnic groups, with specific associations to insulin resistance.Good
- Ethnic disparities in Type 2 Diabetes are influenced by genetic variations regulating lipid and amino acid metabolism, leading to distinct metabolic signatures and drug responses across populations.Good
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