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Preoperative use of GLP-1 receptor agonists is not significantly associated with the odds of postoperative aspiration pneumonia.
Clinicians may reconsider the necessity of withholding GLP-1 RAs preoperatively based on these findings.
StrongRefutesmedium confidence
Adjusted analysis showed no significant differences in the odds of postoperative pneumonia (odds ratio, 0.78; 95% CI, 0.57-1.06; P = .12) between GLP-1 RA users and nonusers.
Why this rating
Based on the large retrospective cohort study design.
Source
Postoperative Aspiration Pneumonia Among Adults Using GLP-1 Receptor Agonists
Yuan-Hsin Chen et al. · JAMA Network Open · 2025
DOI 10.1001/jamanetworkopen.2025.0081
cohort · n=366476Cited 42×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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