Research
Energy balance
Metabolic bariatric surgery (MBS) was associated with greater total weight loss (mean 28.3%) compared to GLP-1 receptor agonists (mean 10.3%) in patients with class II and III obesity.
MBS may be a more effective option for significant weight loss in patients with higher obesity classes.
StrongSupportsmedium confidence
total weight loss was greater for the MBS group (mean [SE], 28.3% [0.3%]) than the GLP-1 RA group (mean [SE], 10.3% [0.5%]) (P < .001).
Why this rating
Based on the large cohort study design.
Source
Obesity Treatment With Bariatric Surgery vs GLP-1 Receptor Agonists
Tyson S. Barrett et al. · JAMA Surgery · 2025
DOI 10.1001/jamasurg.2025.3590
cohort · n=30458Cited 37×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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