Hormonal
Baseline levels of fibroblast growth factor 21 (FGF-21) significantly predict the magnitude of weight loss during the first three months of dietary intervention, whereas other inflammatory and cardiovascular biomarkers do not.
Current blood tests for inflammatory or cardiovascular proteins cannot tell you which diet (low-fat or low-carb) will work best for you. The only protein that showed predictive power for weight loss magnitude was FGF-21, but even that has limited utility for individualized advice. Focus on adherence to a sustainable dietary pattern rather than seeking a predictive blood test.
However, out of 263 proteins analyzed at baseline, only fibroblast growth factor 21 (FGF-21) predicted weight loss, and none helped individualize dietary assignment.
Why this rating
Large randomized trial (N=609) with rigorous statistical correction (FDR < 5%), though replication of the specific prediction was not performed in an independent cohort.
Source
Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention
Sylwia M. Figarska et al. · Scientific Reports · 2020
DOI 10.1038/s41598-020-64636-7
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