Research
Hormonal
Weight loss interventions lead to significant changes in the plasma levels of 130 inflammatory and cardiovascular proteins, with most decreasing alongside BMI reduction.
Losing weight significantly alters your body's inflammatory and cardiovascular protein profile. This confirms that weight loss has systemic biological benefits beyond just size reduction, improving metabolic health markers.
GoodSupportsHIGH confidence
Of 263 tested proteins, 130 were significantly associated with changes in BMI... 118 tracked with BMI (i.e. decreased protein levels upon weight loss; positive beta coefficients), while 12 displayed opposite directions (i.e. increased protein levels upon weight loss; negative beta coefficients).
Why this rating
Large sample size and longitudinal design with replication in a secondary cohort for baseline associations.
Source
Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention
Sylwia M. Figarska et al. · Scientific Reports · 2020
DOI 10.1038/s41598-020-64636-7
rct · n=609Cited 45×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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