Hormonal
Protein hydrolysates do not provide superior muscle protein synthesis (MPS) or anabolic properties compared to intact non-hydrolysed proteins or free amino acids.
If you are taking protein hydrolysates expecting better muscle growth than regular protein, you are likely wasting money. Current evidence shows that intact proteins (like whey isolate or casein) and free amino acids are just as effective for muscle recovery and adaptation. Stick to cost-effective, intact protein sources unless you have specific digestive issues.
However, despite these claims, there is currently insufficient evidence to support superior muscle anabolic properties compared with intact non-hydrolysed proteins and/or free AA controls.
Why this rating
Based on a comprehensive review of multiple studies showing equivocal or negative results for hydrolysates vs. intact proteins.
Source
The role of protein hydrolysates for exercise-induced skeletal muscle recovery and adaptation: a current perspective
Paul T. Morgan et al. · Nutrition & Metabolism · 2021
DOI 10.1186/s12986-021-00574-z
More from this paper
- Protein hydrolysates may induce a more potent insulinotropic effect (higher insulin response) than intact proteins, although this does not necessarily translate to greater muscle protein synthesis.Good
- Protein hydrolysates may be beneficial for older adults or those with slower digestion because they accelerate protein digestion and absorption, reducing splanchnic extraction.Moderate
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