Research
Hormonal
Protein hydrolysates may induce a more potent insulinotropic effect (higher insulin response) than intact proteins, although this does not necessarily translate to greater muscle protein synthesis.
Hydrolysates might spike your insulin more than regular protein, but this doesn't mean you build more muscle. Insulin helps inhibit muscle breakdown, but since MPS is the same, the extra insulin spike is likely unnecessary for most people.
GoodQualifiesMEDIUM confidence
maximum plasma insulin concentration was 28% greater following the ingestion of the whey protein hydrolysate... Together, these findings suggest that protein hydrolysates may induce a more potent insulinotropic effect
Why this rating
Supported by specific studies cited in the review showing higher insulin peaks with hydrolysates.
Source
The role of protein hydrolysates for exercise-induced skeletal muscle recovery and adaptation: a current perspective
Paul T. Morgan et al. · Nutrition & Metabolism · 2021
DOI 10.1186/s12986-021-00574-z
narrative_reviewCited 43×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Protein hydrolysates do not provide superior muscle protein synthesis (MPS) or anabolic properties compared to intact non-hydrolysed proteins or free amino acids.Good
- Protein hydrolysates may be beneficial for older adults or those with slower digestion because they accelerate protein digestion and absorption, reducing splanchnic extraction.Moderate
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