Research
Energy balance
Weight loss interventions, if deemed to be necessary, should be considered carefully.
Practitioners should approach weight loss interventions with caution, considering potential risks.
StrongQualifiesmedium confidence
The findings suggest that an association exists between weight variation and heart disease mortality and that weight loss interventions, if deemed to be necessary, should be considered carefully.
Why this rating
Based on study design from abstract.
Source
Association of Weight Fluctuation With Mortality in Japanese Adults
John Cologne et al. · JAMA Network Open · 2019
DOI 10.1001/jamanetworkopen.2019.0731
cohort · n=4796Cited 30×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Magnitude of residual variation in weight was associated with all-cause mortality (relative risk, 1.25 for 1 U of additional variation; 95% CI, 1.06-1.47).Strong
- Magnitude of residual variation in weight was associated with ischemic heart disease mortality (relative risk, 2.49; 95% CI, 1.41-4.38).Strong
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