Research
Metabolic adaptation
ILI participants with increased waist circumference had an increased risk of primary cardiovascular outcomes, regardless of weight loss or weight gain.
Weight management strategies should also focus on waist circumference reduction to mitigate cardiovascular risks.
StrongSupportsmedium confidence
ILI participants with increased WC had increased risk of primary outcomes, regardless of weight loss (hazard ratio: 1.55 [95% CI: 1.11-2.17]) or weight gain (hazard ratio: 1.76 [95% CI: 1.07-2.89]).
Why this rating
Based on the randomized trial design of the Look AHEAD study.
Source
Waist Circumference Change During Intensive Lifestyle Intervention and Cardiovascular Morbidity and Mortality in the Look AHEAD Trial
KayLoni L. Olson et al. · Obesity · 2020
rct · n=5490Cited 24×
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