Research
Energy balance
Increases in BMI over the past 30 years were not associated with later risk of myocardial infarction or death but were associated with the risk of incident diabetes.
Practitioners should note that long-term increases in BMI may not affect cardiovascular risk but do relate to diabetes risk.
StrongQualifiesmedium confidence
Finally, increases in BMI since 30 years before baseline were not associated with the later risk of MI or death but were associated with the risk of incident diabetes (OR, 1.13; 95% CI, 1.01-1.26).
Why this rating
Based on the cohort study design with a significant sample size.
Source
Risks of Myocardial Infarction, Death, and Diabetes in Identical Twin Pairs With Different Body Mass Indexes
Peter Nordström et al. · JAMA Internal Medicine · 2016
DOI 10.1001/jamainternmed.2016.4104
cohort · n=4046Cited 23×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →