Research
Hormonal
The effect of linolenic acid on food intake and body mass disappears in mice lacking the GDF15 receptor GFRAL.
The presence of the GFRAL receptor is essential for the appetite-suppressing effects of linolenic acid.
StrongSupportsmedium confidence
However, this effect disappeared in mice lacking the GDF15 receptor GFRAL.
Why this rating
The study design indicates a direct investigation of the role of GFRAL in mediating the effects of linolenic acid.
Source
Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis
Dongdong Wang et al. · Diabetes · 2023
DOI 10.2337/db23-0495
otherCited 22×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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