Research
Hormonal
GLP-1 receptor agonists demonstrated a mean systolic BP reduction of -3.37 mmHg and a mean diastolic BP reduction of -1.05 mmHg compared with placebo.
GLP-1 receptor agonists can be considered for managing blood pressure in overweight or obese patients.
StrongSupportsmedium confidence
GLP-1 RAs demonstrated a mean systolic BP (SBP) reduction of -3.37 mmHg [95% confidence interval (CI) -3.95 to -2.80] and a mean diastolic BP (DBP) reduction of -1.05 mmHg (95% CI -1.46 to -0.65) compared with placebo.
Why this rating
Based on the meta-analysis of 30 RCTs.
Source
Effects of glucagon-like peptide-1 receptor agonists on blood pressure in overweight or obese patients: a meta-analysis of randomized controlled trials
Hon Jen Wong et al. · Journal of Hypertension · 2024
DOI 10.1097/hjh.0000000000003903
Meta-analysisCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- The BP reduction effect of GLP-1 RAs was consistent across subgroups for diabetic status, formulation, follow-up duration, and route of administration.Strong
- Meta-regression suggested no significant correlation between BP reduction and baseline characteristics such as age, gender, HbA1c, weight, BMI, and percentage of patients with hypertension.Strong
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