Research
Hormonal
The BP reduction effect of GLP-1 RAs was consistent across subgroups for diabetic status, formulation, follow-up duration, and route of administration.
GLP-1 receptor agonists can be effectively used across different patient subgroups for BP management.
StrongSupportsmedium confidence
This effect was consistent across subgroups for diabetic status, formulation of GLP-1 RA, follow-up duration and route of administration for both SBP and DBP.
Why this rating
Supported by the analysis of multiple RCTs.
Source
Effects of glucagon-like peptide-1 receptor agonists on blood pressure in overweight or obese patients: a meta-analysis of randomized controlled trials
Hon Jen Wong et al. · Journal of Hypertension · 2024
DOI 10.1097/hjh.0000000000003903
Meta-analysisCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1 receptor agonists demonstrated a mean systolic BP reduction of -3.37 mmHg and a mean diastolic BP reduction of -1.05 mmHg compared with placebo.Strong
- Meta-regression suggested no significant correlation between BP reduction and baseline characteristics such as age, gender, HbA1c, weight, BMI, and percentage of patients with hypertension.Strong
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