Research
Hormonal
Newer antiobesity pharmacotherapies, particularly semaglutide and tirzepatide, have shown greater efficacy for weight reduction compared with older medications.
Newer medications may provide better options for weight management in patients with obesity.
StrongSupportsmedium confidence
Newer antiobesity pharmacotherapies, particularly semaglutide and tirzepatide, have shown greater efficacy for weight reduction compared with older medications.
Why this rating
The claim is based on a review of evidence regarding newer pharmacotherapies.
Source
Pharmacotherapy for obesity: recent evolution and implications for cardiovascular risk reduction
Kevin C. Maki et al. · Expert Review of Endocrinology & Metabolism · 2023
DOI 10.1080/17446651.2023.2209176
reviewCited 14×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Bariatric surgery is associated with substantial weight reduction (20-30%) and markedly lower subsequent risk for major adverse cardiovascular events (MACE).Strong
- Lifestyle interventions and older antiobesity pharmacotherapies have been associated with less than 12% body weight reduction and no clear benefit to reduce MACE risk.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →