Research
Hormonal
In postmenopausal females with type 2 diabetes, an intensive lifestyle intervention decreased estradiol levels by 15% and bioavailable testosterone by 13% at year 1.
Practitioners should consider the hormonal changes in females when implementing weight loss interventions.
StrongSupportsmedium confidence
At year 1 in females, ILI decreased E2 by 15% and bioT by 13%.
Why this rating
Based on the large sample size and RCT design of the Look AHEAD study.
Source
Weight Loss Differentially Impacts Sex Hormones in Women and Men With Type 2 Diabetes: Look AHEAD Sex Hormone Study
Wendy L. Bennett et al. · The Journal of Clinical Endocrinology & Metabolism · 2024
DOI 10.1210/clinem/dgae584
cohort · n=1740Cited 13×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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