Research
Hormonal
Changes in waist circumference due to the intensive lifestyle intervention were a significant mediator of sex hormone changes.
Practitioners should consider waist circumference changes when evaluating hormone level changes in patients.
StrongSupportsmedium confidence
Change in waist circumference due to ILI at year 1 was a significant mediator of sex hormone changes.
Why this rating
Based on the large sample size and RCT design of the Look AHEAD study.
Source
Weight Loss Differentially Impacts Sex Hormones in Women and Men With Type 2 Diabetes: Look AHEAD Sex Hormone Study
Wendy L. Bennett et al. · The Journal of Clinical Endocrinology & Metabolism · 2024
DOI 10.1210/clinem/dgae584
cohort · n=1740Cited 13×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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