Metabolic adaptation
Youth who achieved 5-6 goals had a higher insulin sensitivity (8.5 ± 4.3 mg/kg/min) compared to those who met 0-3 goals (5.2 ± 3.4 mg/kg/min, P = .003).
Practitioners should encourage adolescents with type 1 diabetes to meet ADA/ISPAD goals to improve insulin sensitivity.
IS was lower in youth who met 0-3 goals (5.2 ± 3.4 mg/kg/min) vs those who met 5-6 goals (8.5 ± 4.3 mg/kg/min, P = .003).
Why this rating
Based on the study design involving multiple cohorts.
Source
Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies
Petter Bjornstad et al. · Pediatric Diabetes · 2017
DOI 10.1111/pedi.12598
More from this paper
- Youth with type 1 diabetes who achieved 4 goals had a higher insulin sensitivity (7.4 ± 4.1 mg/kg/min) compared to those who met 0-3 goals (5.2 ± 3.4 mg/kg/min, P = .04).Strong
- ADA/ISPAD goal achievement was associated with greater cardiopulmonary fitness, with VO2peak values significantly higher in those meeting more goals.Strong
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