Research
Energy balance
GLP-1 receptor agonists were originally developed as glucose lowering agents.
Understanding the original purpose of GLP-1 receptor agonists can inform their use in weight management.
StrongSupportsmedium confidence
Although originally developed as glucose lowering agents for people with type 2 diabetes.
Why this rating
Based on historical context provided in the abstract.
Source
Slow and Steady Wins the Race: 25 Years Developing the GLP-1 Receptor as an Effective Target for Weight Loss
Nitya Kumar et al. · The Journal of Clinical Endocrinology & Metabolism · 2022
DOI 10.1210/clinem/dgac276
reviewCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →