Research
Hormonal
All 3 eligible maintenance doses of tirzepatide (5, 10, and 15 mg once a week) were effective in increasing total cholesterol (TC), HDL-C, VLDL-C, triglyceride (TG), and waist circumference (WC) changes from baseline compared with control agents.
Tirzepatide may be considered as an effective treatment option for improving lipid profiles and waist circumference in patients with type 2 diabetes.
StrongSupportsmedium confidence
All 3 eligible maintenance doses of tirzepatide (5, 10, and 15 mg once a week) were effective in increasing total cholesterol (TC) (P < 0.05), HDL-C (P < 0.05), VLDL-C (P < 0.01), triglyceride (TG) (P < 0.01), and WC (P < 0.01) changes from baseline compared with control agents including placebo, semaglutide, dulaglutide, and degludec.
Why this rating
The claim is supported by a meta-analysis of 7 randomized controlled trials.
Source
Effect of the Dual Glucose‐Dependent Insulinotropic Peptide/Gulcagon‐like Peptide 1 Receptor Agonist Tirzepatide on Lipid Profile and Waist Circumference: A Systematic Review and Meta‐analysis
Dan Yu et al. · Clinical Therapeutics · 2023
Meta-analysisCited 12×
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