Research
Energy balance
Replacing 2% of energy from carbohydrates with plant-based protein or polyunsaturated fatty acids is associated with 23% to approximately 37% lower total mortality.
Encouraging small dietary changes, such as substituting carbohydrates with plant-based proteins or healthy fats, may significantly lower mortality risk.
GoodSupportsmedium confidence
Isocalorically replacing 2% of energy from carbohydrates with plant-based protein or polyunsaturated fatty acids was associated with 23% to approximately 37% lower total mortality.
Why this rating
Based on a prospective cohort study design.
Source
Associations of Moderate Low-Carbohydrate Diets With Mortality Among Patients With Type 2 Diabetes: A Prospective Cohort Study
Zhenzhen Wan et al. · The Journal of Clinical Endocrinology & Metabolism · 2022
DOI 10.1210/clinem/dgac235
cohort · n=5677Cited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Patients in the third quartile of overall lower-carbohydrate diet score had a 35% lower risk of mortality (HR: 0.65; 95% CI, 0.50-0.85) compared to the first quartile.Good
- Adherence to a healthy lower-carbohydrate diet score is associated with lower mortality risk, with HRs of 0.78, 0.73, and 0.74 across quartiles compared to the reference.Good
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