Research
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Real-world evidence suggests slower tirzepatide dose escalation than in clinical trials.
Practitioners may need to adjust expectations regarding dose escalation in real-world settings.
StrongSupportsmedium confidence
Real-world evidence suggests multimorbidity among tirzepatide initiators, slower tirzepatide dose escalation than in clinical trials.
Why this rating
Based on the retrospective observational study design with a substantial sample size.
Source
Real-world use and effectiveness of tirzepatide among people without evidence of type 2 diabetes in the United States
Emily R. Hankosky et al. · Diabetes & Metabolism · 2025
DOI 10.1016/j.diabet.2025.101636
cohort · n=4177Cited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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