Research
Metabolic adaptation
Testosterone replacement therapy significantly improved insulin resistance as measured by HOMA-IR from 4.6 ± 1.7 to 0.5 ± 0.2 (P < 0.001).
Testosterone replacement therapy may be effective in improving insulin sensitivity in hypogonadal patients.
StrongSupportsmedium confidence
Homeostasis model assessment of insulin resistance (HOMA-IR) (4.6 ± 1.7 vs. 0.5 ± 0.2, P < 0.001) were improved significantly following testosterone replacement.
Why this rating
Based on the prospective longitudinal intervention study design.
Source
Effect of testosterone replacement therapy on insulin sensitivity and body composition in congenital hypogonadism
KCO Reddy et al. · Journal of Postgraduate Medicine · 2021
cohort · n=33Cited 10×
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