Research
Hormonal
Weight loss in both diet groups seems to have been driven by the reduction of glycemic load (GL) more so than dietary fat or calories.
Reducing glycemic load may be more effective for weight loss than focusing solely on fat or calorie reduction.
StrongSupportsmedium confidence
As predicted by the carbohydrate–insulin model of obesity, weight loss in both diet groups of DIETFITS seems to have been driven by the reduction of GL more so than dietary fat or calories.
Why this rating
Based on the large randomized controlled trial design.
Source
Evidence for the carbohydrate–insulin model in a reanalysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial
Adrián Soto-Mota et al. · American Journal of Clinical Nutrition · 2023
DOI 10.1016/j.ajcnut.2022.12.014
cohort · n=609Cited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →