Research
Metabolic adaptation
Lifestyle modification alone is often insufficient to achieve clinically meaningful weight loss.
Clinicians should consider pharmacotherapy in conjunction with lifestyle changes for effective weight management.
StrongSupportsmedium confidence
However, lifestyle modification alone is often insufficient to achieve clinically meaningful weight loss due to physiological mechanisms that limit weight reduction and promote weight regain.
Why this rating
The statement is based on a broad understanding of obesity management.
Source
Tirzepatide for Weight Loss: Can Medical Therapy “Outweigh” Bariatric Surgery?
Joel Novograd et al. · Cardiology in Review · 2023
reviewCited 10×
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