Research
Energy balance
Difficulties in achieving body weight loss and maintenance in obese subjects are partly due to physiological regulatory systems that resist weight loss.
Recognizing these physiological challenges can guide effective weight loss strategies.
StrongSupportsmedium confidence
The difficulties of achieving BW loss and maintenance of reduced BW in obese subjects are due, in part, to the operation of the same physiological regulatory system that helps maintain a healthy BW in individuals without obesity.
Why this rating
The claim is supported by research findings discussed in the abstract.
Source
The (dys)regulation of energy storage in obesity
Barry E. Levin et al. · Physiological Reviews · 2025
DOI 10.1152/physrev.00002.2024
reviewCited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →