Research
Energy balance
Glucagon receptor activation in triple agonists increases energy expenditure and lipid oxidation, contributing to weight loss without causing hyperglycemia when combined with GLP-1 and GIP.
The addition of glucagon receptor activation in triple agonists helps burn more energy and fat, contributing to weight loss without raising blood sugar, thanks to the balancing effects of GLP-1 and GIP.
GoodSupportsHIGH confidence
The mechanism of action is attributed to the GIP/GLP-1 receptor co-agonism being enhanced by glucagon receptor activation and augmentation of energy intake, substrate utilisation and energy expenditure
Why this rating
Supported by preclinical and Phase 1/2 data.
Source
The Road towards Triple Agonists: Glucagon-Like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Glucagon Receptor - An Update
Agnieszka Jakubowska et al. · Endocrinology and Metabolism · 2024
DOI 10.3803/enm.2024.1942
narrative_reviewCited 36×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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