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Tirzepatide achieved similar 12-month TBWL% as R-ESG (13.2% vs. 13.4%, p = .9) and significantly more than semaglutide (13.2% vs. 8.1%, p = .04).
Tirzepatide may be a viable alternative for weight loss in patients post-sleeve gastrectomy, potentially outperforming semaglutide.
StrongSupportsmedium confidence
On subgroup analysis, tirzepatide achieved similar 12-months TBWL% as R-ESG (13.2% vs. 13.4%, p = .9) and significantly more than semaglutide (13.2% vs. 8.1%, p = .04).
Why this rating
The study is a retrospective analysis with a significant sample size.
Source
Revisional endoscopic sleeve gastroplasty versus semaglutide and tirzepatide for weight recidivism after sleeve gastrectomy
Firas Bahdi et al. · Clinical Obesity · 2025
DOI 10.1111/cob.70001
cohort · n=90Cited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- R-ESG offered higher total body weight loss (TBWL%) than GLP1/GIP-RA at 3 months (11.2% vs. 4.3%, p < .001), 6 months (13.5% vs. 6.8%, p < .001), and 12 months (13.4% vs. 9.2%, p = .07).Strong
- GLP1/GIP-RA achieved significantly lower TBWL% in patients with prior SG compared to those with intact stomach at 3 months (4.3% vs. 5.7%, p = .02), 6 months (6.8% vs. 9.2%, p = .02), and 12 months (9.2% vs. 12.7%, p = .03).Strong
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