Research
Energy balance
No significant further benefits of ingesting multi-ingredient supplements (MTN) compared to calorie equivalent comparator (COMP) supplements were identified for fat-free mass (FFM), upper-body strength, lower-body strength, and functional capacity.
Practitioners should consider that multi-ingredient supplements may not provide additional benefits over calorie equivalent supplements for body composition and performance in this population.
StrongRefutesmedium confidence
Compared to COMP, no significant further benefits of ingesting MTN were identified for FFM (kg) (g = 0.044, 95 % CI -0.14 to 0.22), upper-body strength (kg) (g = 0.046, 95 % CI -0.24 to 0.33), lower-body strength, leg press exercise (kg) (g = 0.025, 95 % CI -0.26 to 0.31), leg extension exercise (kg) (g = 0.106, 95 % CI -0.15 to 0.36) and functional capacity (time in seconds) (g = 0.079, 95 % CI -0.12 to 0.27).
Why this rating
Based on systematic review and meta-analysis of RCTs.
Source
No impact of combining multi-ingredient supplementation with exercise on body composition and physical performance, in healthy middle-aged and older adults: A systematic review and meta-analysis
Joel Puente-Fernández et al. · Experimental Gerontology · 2022
DOI 10.1016/j.exger.2022.112079
Meta-analysisCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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